A study conducted in a tertiary care hospital to assess the cardiac function in paediatric beta thalassemia major patients and correlation with serum ferritin levels which are indicative of chelation status of the patients

Background: Thalassemia is one of the common inherited blood disorders and Beta Major a homozygous form deficiency beta globin chain synthesis causing severe transfusion-dependent anemia, manifesting between 6 24 months life. Objectives: The objective study to pattern cardiac function in children adolescents with beta-thalassemia major by 2D Echocardiography its correlation serum ferritin levels. Methods: Fifty subjects diagnosed Major, after applying inclusion exclusion criteria were included Group 1, 50 age gender-matched without 2. Serum level was measured using Cobas 6000 analyzer. done following parameters: Posterior wall thickness-diastolic (PWT-D), posterior thickness- systolic (PWT-S), left ventricular internal diameter-diastole (LVID-D), diameter-systole (LVID-S), septal thickness tricuspid regurgitation (TR) velocity. Results: Among population, 28 belonged group 5–10 years (56%) 22 10–15 (44%). parameters, PWT-D, PWT-S, LVID-D, LVID-S, TR velocity, values higher cases compared control p suggesting strong significance. ejection fraction lower than strongly significant p-value. Conclusion: Children thalassemia have impaired degree dysfunction correlated Regular transfusion adequate chelation are essential decrease morbidity mortality.